Cailyn H. Spurrell

This paper develops a CRISPRa-based method to identify genes enhancing CAR T cell survival in different tumor environments.

The paper uses single-nucleus ATAC-Seq and RNA-Seq to analyze age and sex differences in human heart cells, identifying gene expression and chromatin changes linked to these factors.

This study designs and tests STAT-activating scaffolds to enhance CAR T cell anti-tumor potency, finding that LASI-3 improves function without lymphoproliferative side effects.

The paper creates a single-cell multi-omic atlas of the rhesus macaque brain, identifying cell-type-specific regulatory elements and providing insights into brain evolution and disease.

The paper identifies 14,000 human craniofacial enhancers across developmental stages and shows 56% are conserved in mice, providing cell type- and stage-specific activity profiles.

The paper identifies widespread epigenomic changes in idiopathic dilated cardiomyopathy, showing a shift toward fetal-like enhancer states and providing a data resource for further study.

The paper establishes a single-cell atlas of human tooth development and uses it to guide the in vitro differentiation of ameloblasts from iPSCs, developing a mineralizing enamel organoid system.

This study identifies a gene desert critical for Shox2 regulation and embryonic survival through enhancer networks in mouse development.