The Neonatal Myeloid Hypoxia Response Promotes a Cardiac Regenerative Response through Insulin-Like Growth Factor
Amanda Becker, Connor W. Lantz, Aparna Anathakrishman, Matthew DeBerge, Kristofor E. Glinton, Zhi‐Dong Ge, Edward Benjamin Thorp
This study shows that myeloid Hif1 is essential for neonatal cardiac regeneration via IGF-1 signaling, as its loss impairs regenerative function and increases myocardial scarring.
bioRxiv · Apr 21, 2026 · PreprintImmunology