Amanda Becker

This study shows that myeloid Hif1 is essential for neonatal cardiac regeneration via IGF-1 signaling, as its loss impairs regenerative function and increases myocardial scarring.

The paper identifies age-specific secretome differences in macrophages under hypoxia and LPS, showing neonatal macrophages have anti-inflammatory, regenerative properties dependent on HIF-1, while adult macrophages show pro-inflammatory, glycolytic responses.