AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma
Daniel Angelov, James Nolan, Gráinne Holland, Darragh Nimmo, Molly Davies, Craig Monger, Eugène Dillon, Marlena Mucha, Cheng Wang, Dáire Gannon, Eimear Lagan, Andrew A. Malcolm, Lu Yang, April Chen, Elisabeth Vandenberghe, , Adrian P. Bracken
This study identifies AEBP2 as a therapeutic target in EZH2-mutant lymphoma by showing its role in maintaining H3K27me2 levels through a PRC2.2 complex.
bioRxiv · Oct 14, 2025 · PreprintCancer Biology