Author

Adrian P. Bracken

Trinity College DublinORCID 0000-0002-1547-9443Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Craig MongeriD· 3 shared Darragh NimmoiD· 2 shared Eimear LaganiD· 2 shared Eric ConwayiD· 2 shared Gerard L. BrieniD· 2 shared Andrew A. MalcolmiD· 1 shared Andrew FlausiD· 1 shared Anthony M. DohertyiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

Craig MongerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity

Anthony M. Doherty, Eimear Lagan, Richard J. R. Elliott, Kieran J. Wynne, Craig Monger, Adrian P. Bracken, Junwei Shi, Christopher R. Vakoc, Scott A. Armstrong, Giorgio Oliviero, Christoper Ott, Neil O. Carragher, Gerard L. Brien

This study shows SS18-SSX sustains oncogenic transcription without needing SWI/SNF activity, identifies P300 as a critical co-factor, and demonstrates targeting P300 or SWI/SNF as therapeutic strategies.

bioRxiv · Jan 27, 2026 · PreprintCancer Biology

AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma

Daniel Angelov, James Nolan, Gráinne Holland, Darragh Nimmo, Molly Davies, Craig Monger, Eugène Dillon, Marlena Mucha, Cheng Wang, Dáire Gannon, Eimear Lagan, Andrew A. Malcolm, Lu Yang, April Chen, Elisabeth Vandenberghe, , Adrian P. Bracken

This study identifies AEBP2 as a therapeutic target in EZH2-mutant lymphoma by showing its role in maintaining H3K27me2 levels through a PRC2.2 complex.

bioRxiv · Oct 14, 2025 · PreprintCancer Biology

Dominant negative effects on H3K27 methylation by Weaver syndrome-associated EZH2 variants

Orla Deevy, Craig Monger, Francesca Matrà, Ellen Tuck, Eric Conway, Mihaly Badonyi, Darragh Nimmo, Simona Rodighiero, Qi Zhang, Chen Davidovich, Joseph A. Marsh, Diego Pasini, Adrian P. Bracken

This study investigates EZH2 variants linked to Weaver syndrome, showing they cause dominant negative effects on H3K27 methylation, altering chromatin states and contributing to developmental disorders.

bioRxiv · Jun 1, 2023 · PreprintGenetics