This study investigates the effects of NOTCH3 suppression in human vascular smooth muscle cells, revealing changes in extracellular matrix, cytoskeletal organization, and metabolic pathways.

bioRxiv · Aug 28, 2026 · PreprintMolecular Biology

Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin

Emma J. Doyle, Maeve Boyce, Sarah Buggle, Taylor Smith, Eugène Dillon, Anthony M. McElligott, Nina M. Orfali, Aisling Y. Coughlan, Diego Pasini, Eric Conway

The paper shows that pathogenic PR-DUB complex variants reduce H2AK119ub1 levels by stabilizing truncated ASXL1, leading to PRC2 displacement and H3K27me3 reduction, a phenotype shared across different chromatinopathies.

bioRxiv · Jul 26, 2026 · PreprintGenetics

AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma

Daniel Angelov, James Nolan, Gráinne Holland, Darragh Nimmo, Molly Davies, Craig Monger, Eugène Dillon, Marlena Mucha, Cheng Wang, Dáire Gannon, Eimear Lagan, Andrew A. Malcolm, Lu Yang, April Chen, Elisabeth Vandenberghe, , Adrian P. Bracken

This study identifies AEBP2 as a therapeutic target in EZH2-mutant lymphoma by showing its role in maintaining H3K27me2 levels through a PRC2.2 complex.

bioRxiv · Oct 14, 2025 · PreprintCancer Biology