Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface
John D. Hulleman, Seungje Jeon, Sofia Bali, Sophia M. DiCesare, Ali Abbas, Steffi Daniel, Antonio J. Ortega, Gracen E. Collier, Julian Yang, Archishman Bhattacharyaa, Melissa K. McCoy, Łukasz A. Joachimiak, Bruce A. Posner
This paper identifies specific azo compounds that enhance HTRA1 abundance but have varying effects on its activity, suggesting potential therapeutic applications for diseases like AMD.
ACS Chemical Biology · Jul 30, 2025Peer-reviewedBiochemistry