Author

Antonio J. Ortega

University of Minnesota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Gracen E. CollieriD· 3 shared John D. HullemaniD· 3 shared Steffi Daniel· 3 shared Bruce A. PosneriD· 2 shared Krista N. Thompson· 2 shared Melissa K. McCoyiD· 2 shared Sophia M. DiCesare· 2 shared Ali AbbasiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

Gracen E. CollierORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genetic removal of Nlrp3 protects against sporadic and R345W Efemp1-induced basal laminar deposit formation

Antonio J. Ortega, Steffi Daniel, Marian Renwick, Pravallika Kambhampati, Krista N. Thompson, Gracen E. Collier, Emily L. Baker, Hasan Zaki, John D. Hulleman

This study shows that removing Nlrp3 reduces basal laminar deposits in both a genetic mouse model and wild-type mice, suggesting a role for Nlrp3 in AMD pathology.

Cell Death and Disease · Nov 6, 2025Peer-reviewedImmunology

Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface

John D. Hulleman, Seungje Jeon, Sofia Bali, Sophia M. DiCesare, Ali Abbas, Steffi Daniel, Antonio J. Ortega, Gracen E. Collier, Julian Yang, Archishman Bhattacharyaa, Melissa K. McCoy, Łukasz A. Joachimiak, Bruce A. Posner

This paper identifies specific azo compounds that enhance HTRA1 abundance but have varying effects on its activity, suggesting potential therapeutic applications for diseases like AMD.

ACS Chemical Biology · Jul 30, 2025Peer-reviewedBiochemistry

GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology

Sophia M. DiCesare, Antonio J. Ortega, Gracen E. Collier, Steffi Daniel, Krista N. Thompson, Melissa K. McCoy, Bruce A. Posner, John D. Hulleman

The paper shows that GSK3 inhibition reduces fibulin-3 production and prevents AMD-like pathology in a mouse model of ML/DHRD.

JCI Insight · Aug 7, 2024Peer-reviewedNeuroscience