Sofia Bali

This study identifies a hybrid inflammasome formed by NLRP1 and NLRP3 in human cells, associated with inflammation in inflammasomopathies and transplant patients.

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

This study identifies Mac1 as a therapeutic target for SARS-CoV-2 and demonstrates that AVI-4206, a small molecule inhibitor, reduces viral replication and improves survival in an animal model.

This study shows DnaJB1 inhibits tau aggregation by binding its N-terminus in vitro and in cellular models, with interactions enhanced by polyanionic factors.

This paper identifies specific azo compounds that enhance HTRA1 abundance but have varying effects on its activity, suggesting potential therapeutic applications for diseases like AMD.