Melissa K. McCoy

This paper introduces Subtimizer, a computational pipeline for designing potent and selective kinase peptide substrates using AI tools, showing improved activity and selectivity in tested kinases.

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

This paper identifies specific azo compounds that enhance HTRA1 abundance but have varying effects on its activity, suggesting potential therapeutic applications for diseases like AMD.

This study investigates drug-drug interactions in AML cell lines, finding widespread but non-conserved synergistic and antagonistic effects across different cell lines.

The paper shows that GSK3 inhibition reduces fibulin-3 production and prevents AMD-like pathology in a mouse model of ML/DHRD.