Molecular determinants underlying substrate receptor specificity of human CRL4B E3 ubiquitin ligase
Weaam I Mohamed, Julius Rabl, Bilal Muhammad Qureshi, Alexander Leitner, Federico Uliana, Arghavan Kazemzadeh, Noha Radwan, Matthias Peter
This study identifies molecular determinants that guide DCAF specificity for CUL4B in the CRL4B E3 ubiquitin ligase complex through structural and biochemical analyses.
bioRxiv · Mar 15, 2026 · PreprintBiochemistry