The paper presents the cryo-EM structure of a β1-adrenoceptor-AmpC β-lactamase fusion protein in the inactive state, revealing conformational dynamics and potential for GPCR structure elucidation.

Journal of Structural Biology · Jul 16, 2026Peer-reviewedMolecular Biology

Molecular determinants underlying substrate receptor specificity of human CRL4B E3 ubiquitin ligase

Weaam I Mohamed, Julius Rabl, Bilal Muhammad Qureshi, Alexander Leitner, Federico Uliana, Arghavan Kazemzadeh, Noha Radwan, Matthias Peter

This study identifies molecular determinants that guide DCAF specificity for CUL4B in the CRL4B E3 ubiquitin ligase complex through structural and biochemical analyses.

bioRxiv · Mar 15, 2026 · PreprintBiochemistry

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

Eric J. Aird, Julius Rabl, Tabea Knuesel, Kevin Groen, Samah W. Awwad, Boris Korablev, Lynn Scherpe, Waleed Al–Herz, Robin Hupfer, Mike Recher, Stephen P. Jackson, Benjamin G. Hale, Jacob E. Corn

The paper identifies SP110 as a negative regulator of type 1 interferon-driven cell death by counteracting SP100's toxic filament formation through CARD domain interactions.

Nature Cell Biology · Mar 13, 2026Peer-reviewedImmunology

Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding ofproteins with alpha helical domains

Arka Banerjee, Meriç Ataman, Maciej Jerzy Smialek, Debdatto Mookherjee, Julius Rabl, Andrey A. Mironov, Lea Mues, Ludovic Enkler, Mairene Coto‐Llerena, Alexander Schmidt, Daniel Boehringer, Salvatore Piscuoglio, Anne Spang, Nitish Mittal, Mihaela Zavolan

This study identifies RPL39L as an efficiency factor in cotranslational folding of alpha helical proteins by analyzing its expression, ribosome structure, and impact on translation dynamics.

bioRxiv · Apr 3, 2023 · PreprintMolecular Biology