Gastruloids develop the three body axes in the absence of extraembryonic tissues and spatially localised signalling
David A. Turner, M. Girgin, Luz Alonso‐Crisostomo, Vikas Trivedi, Peter Baillie‐Johnson, C. R. Glodowski, Penny Hayward, Jérôme Collignon, Carsten R. Gustavsen, Palle Serup, Benjamin Steventon, Matthias P. Lütolf, Arias A. Martinez
Mouse embryonic stem cell aggregates (Gastruloids) form anteroposterior, dorsoventral and left-right axes without extraembryonic tissue or localised signals, through Nodal-initiated, Wnt-stabilised T/Brachyury polarisation.
Development · Jan 1, 2017Peer-reviewedDevelopmental Biology✦ In-depth digest