Vikas Trivedi

This study develops an iPSC-based model with enhanced endothelial identity to study malaria parasite interactions and pathogenesis in vitro.

This study identifies basal fluidization in human neuroepithelia as a tissue-level mechanism driving forebrain expansion, distinct from other great apes and mice.

The paper shows that glycolytic activity regulates germ layer proportions by modulating Nodal and Wnt signalling in mouse gastrulation.

This study investigates how varying proportions of primed and naive ESCs affect gastruloid formation and AP axial patterning, revealing developmental flexibility in mammalian embryogenesis.

The paper shows that collective cell fate decisions and mechanical differences drive symmetry breaking in gastruloids through a mechanochemical mechanism.

The paper uses stem cell differentiation to study developmental tempo scaling across mammals and finds that segmentation clock periods correlate with phylogeny and biochemical kinetics of HES7, but not metabolic rates.

This paper introduces a Bayesian deconvolution method to separate signal from noise in single-cell measurements, applied to study Brachyury expression in differentiating mouse embryonic stem cells.

linus provides an interactive web-based tool for exploring and sharing large-scale biological trajectory data.

The paper studies AP axis establishment in gastruloids using scRNA-seq and identifies molecular signatures of germ layer commitment and differences between Bra/T+ and Bra/T- populations.

The paper shows that zebrafish embryos can break symmetry autonomously when isolated, indicating that extra-embryonic tissues are not strictly required for early patterning.

This paper introduces a method to quantitatively analyze mRNA expression in whole vertebrate embryos with subcellular resolution, enabling both anatomical to expression and expression to anatomical queries.

Mouse embryonic stem cell aggregates (Gastruloids) form anteroposterior, dorsoventral and left-right axes without extraembryonic tissue or localised signals, through Nodal-initiated, Wnt-stabilised T/Brachyury polarisation.