Peter Baillie‐Johnson

This study shows that mouse gastruloids generate PGC-like cells (Gld-PGCLCs) through self-organized interactions, mimicking in vivo PGC development without exogenous signals.

The paper identifies a multipotent progenitor population derived from Epiblast Stem Cells that self-renew and express a gene signature similar to embryonic NMPs.

This study compares the ability of mouse ES cell-derived progenitors to generate NMp behavior in vivo, finding that NMp competence is lost in anterior gastruloids.

Mouse embryonic stem cell aggregates (Gastruloids) form anteroposterior, dorsoventral and left-right axes without extraembryonic tissue or localised signals, through Nodal-initiated, Wnt-stabilised T/Brachyury polarisation.

This study uses Gastruloids to show that Nodal and Wnt signaling interactions drive symmetry breaking and axial organization in early development.