A massively parallel reporter screen defines the syntax of SECReTE, a secretion-enhancing cis regulatory targeting element, in mammalian cells
Gal Haimovich, Gabriela Lobinsky, Shu‐Ting You, Dvir Schirman, Frida Grynspan, Ariel Gilbert, Orna Dahan, Tsviya Olender, Jeffrey E. Gerst, Yitzhak Pilpel
The paper identifies the syntax of SECReTE, a secretion-enhancing cis regulatory element, through a parallel reporter screen in mammalian cells, revealing key sequence patterns and their impact on mRNA localization and protein secretion.
bioRxiv · Oct 14, 2026 · PreprintCell Biology