Jeffrey E. Gerst

The paper identifies the syntax of SECReTE, a secretion-enhancing cis regulatory element, through a parallel reporter screen in mammalian cells, revealing key sequence patterns and their impact on mRNA localization and protein secretion.

This study shows that intercellular mRNA transfer via tunneling nanotubes can complement genetic mutations in vitro, as demonstrated by peroxisome biogenesis in Zellweger Syndrome models.

The paper shows mammalian HSP mRNAs form RNA assemblages during heat stress, similar to prokaryotic operons, and identifies a conserved sequence motif critical for this process.

EASI-ORC automates smFISH image analysis in yeast to measure RNA-organelle colocalization, offering a fast, accurate, and user-friendly solution.

The paper identifies SECReTE cis-acting RNA motifs in SARS-CoV-2 and other (+)ssRNA viruses, showing their association with ER-related functions and potential as drug targets.