Dvir Schirman

The paper identifies the syntax of SECReTE, a secretion-enhancing cis regulatory element, through a parallel reporter screen in mammalian cells, revealing key sequence patterns and their impact on mRNA localization and protein secretion.

The paper describes a project from the 4D Nucleome Hackathon aimed at developing a workflow for comparing and validating chromatin models, identifying challenges in model comparison and software development.

This study uses live-cell imaging of fluorescently labeled loci in E. coli to inform a dynamic polymer model of chromosome organization across the cell cycle, revealing global reorganization of the chromosome structure.

The paper investigates how intronic sequence features influence splicing efficiency and mRNA expression in yeast, revealing evolutionary adaptations and mechanisms of alternative splicing.