Dynamic and Biphasic Regulation of Cell Migration by Ras
Yiyan Lin, Eleana Parajón, Qinling Yuan, Siyu Ye, Guanghui Qin, Yu Deng, Jane A. Borleis, Ariel Koyfman, Pablo A. Iglesias, Κωνσταντίνος Κωνσταντόπουλος, Douglas N. Robinson, Peter N. Devreotes
This study shows that Ras activity has a biphasic effect on cell migration, with both high and low activity impairing movement, and reveals that Ras regulates migration through rapid, non-transcriptional mechanisms.
bioRxiv · Feb 13, 2025 · PreprintCell Biology