Author

Yu Deng

Johns Hopkins UniversityORCID 0000-0002-0673-1352Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yu Deng2 papers · Guangzhou Women and Children Medical Center

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Organism:Drosophila· 2 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:optimal transport· 1 Assay:proteomics· 1

Frequent Co-Authors

Pablo A. IglesiasiD· 3 shared Peter N. DevreotesiD· 3 shared Dhiman Sankar PaliD· 2 shared Jane A. Borleis· 2 shared Parijat Banerjee· 2 shared Tatsat BanerjeeiD· 2 shared Ariel Koyfman· 1 shared Debojyoti BiswasiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

Pablo A. IglesiasORCID

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3 papers

Recent·Most cited

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration

Yu Deng, Tatsat Banerjee, Satomi Matsuoka, Debojyoti Biswas, Liz A. Kurtz, Jane A. Borleis, Yu Long, Parijat Banerjee, Huiwang Zhan, Dhiman Sankar Pal, Nathan H. Roy, Masahiro Ueda, Pablo A. Iglesias, Peter N. Devreotes

This study identifies a PIP5K-Ras bistable circuit that drives plasma membrane symmetry breaking, leading to cellular polarity and migration.

Nature Communications · Sep 30, 2026Peer-reviewedCell Biology

Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study

Parijat Banerjee, Jonathan A. Kuhn, Dhiman Sankar Pal, Yu Deng, Tatsat Banerjee, Peter N. Devreotes, Pablo A. Iglesias

This study uses computational models to investigate how feedback loops in Dictyostelium cells influence polarization, finding that global inhibition is more robust than local inhibition.

PLoS Computational Biology · Oct 9, 2025Peer-reviewedCell Biology

Dynamic and Biphasic Regulation of Cell Migration by Ras

Yiyan Lin, Eleana Parajón, Qinling Yuan, Siyu Ye, Guanghui Qin, Yu Deng, Jane A. Borleis, Ariel Koyfman, Pablo A. Iglesias, Κωνσταντίνος Κωνσταντόπουλος, Douglas N. Robinson, Peter N. Devreotes

This study shows that Ras activity has a biphasic effect on cell migration, with both high and low activity impairing movement, and reveals that Ras regulates migration through rapid, non-transcriptional mechanisms.

bioRxiv · Feb 13, 2025 · PreprintCell Biology