Pablo A. Iglesias

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration

This study identifies a PIP5K-Ras bistable circuit that drives plasma membrane symmetry breaking, leading to cellular polarity and migration.

Contributions of single-cell mechanics and cell-cell adhesion to multicellular spheroid mechanics

This study uses a computational model to show that cell-cell adhesion has a greater impact on spheroid elasticity than single-cell stiffness, while both influence viscoelastic relaxation.

Membrane Kymograph Generator: A cross-platform GUI software for automated generation and analysis of kymographs along dynamic cell boundaries

The paper introduces Membrane Kymograph Generator, a software tool for automated kymograph generation and analysis of membrane dynamics from live-cell imaging data.

Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study

This study uses computational models to investigate how feedback loops in Dictyostelium cells influence polarization, finding that global inhibition is more robust than local inhibition.

Dynamic and Biphasic Regulation of Cell Migration by Ras

This study shows that Ras activity has a biphasic effect on cell migration, with both high and low activity impairing movement, and reveals that Ras regulates migration through rapid, non-transcriptional mechanisms.

Learning stochastic reaction-diffusion models from limiteddata using spatiotemporal features

This paper learns stochastic reaction-diffusion models from limited and noisy data using spatiotemporal features and sparsity enforcement.

Synthetic control of actin polymerization and symmetry breaking in activeprotocells

The paper demonstrates symmetry breaking in an active protocellular system through externally-controlled actin polymerization in giant unilamellar vesicles.

Enhanced chemotaxis through spatially-regulated absolute concentration robustness

The paper shows how spatially-regulated absolute concentration robustness improves chemotactic efficiency by suppressing unwanted protrusions in cells.

Thalamocortical network connectivity controls spatiotemporal dynamics of cortical and thalamic traveling waves

This paper develops a computational model of a thalamocortical network to study how connectivity and delays affect spatiotemporal traveling wave patterns in the cortex and thalamus.