Author

Jane A. Borleis

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Organism:human· 1 Organism:mouse· 1 Approach:optimal transport· 1

Frequent Co-Authors

Peter N. DevreotesiD· 3 shared Pablo A. IglesiasiD· 2 shared Yu DengiD· 2 shared Ariel Koyfman· 1 shared Bianca N. Fernandez· 1 shared Debojyoti BiswasiD· 1 shared Dhiman Sankar PaliD· 1 shared Douglas N. RobinsoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

Peter N. DevreotesORCID

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Author profile →

3 papers

Recent·Most cited

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration

Yu Deng, Tatsat Banerjee, Satomi Matsuoka, Debojyoti Biswas, Liz A. Kurtz, Jane A. Borleis, Yu Long, Parijat Banerjee, Huiwang Zhan, Dhiman Sankar Pal, Nathan H. Roy, Masahiro Ueda, Pablo A. Iglesias, Peter N. Devreotes

This study identifies a PIP5K-Ras bistable circuit that drives plasma membrane symmetry breaking, leading to cellular polarity and migration.

Nature Communications · Sep 30, 2026Peer-reviewedCell Biology

Dynamic and Biphasic Regulation of Cell Migration by Ras

Yiyan Lin, Eleana Parajón, Qinling Yuan, Siyu Ye, Guanghui Qin, Yu Deng, Jane A. Borleis, Ariel Koyfman, Pablo A. Iglesias, Κωνσταντίνος Κωνσταντόπουλος, Douglas N. Robinson, Peter N. Devreotes

This study shows that Ras activity has a biphasic effect on cell migration, with both high and low activity impairing movement, and reveals that Ras regulates migration through rapid, non-transcriptional mechanisms.

bioRxiv · Feb 13, 2025 · PreprintCell Biology

A negative feedback loop between small GTPase Rap1 and mammalian tumor suppressor homolog KrsB regulates cell-substrate adhesion in Dictyostelium

Yulia Artemenko, Gengle Niu, Megan E. Arnold, Kelsey E. Roberts, Bianca N. Fernandez, Tiffany Flores, Harper D. McClave, Michael Paestella, Jane A. Borleis, Peter N. Devreotes

Molecular Biology of the Cell · Feb 12, 2025Peer-reviewedCell Biology