Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis
Gwendoline Astre, Tehila Atlan, Uri Goshtchevsky, Adi Oron-Gottesman, Margarita Smirnov, Kobi Shapira, Ariel Velan, Joris Deelen, Tomer Levy, Erez Y. Levanon, Itamar Harel
This study shows that mutating APRT in turquoise killifish extends male lifespan and improves metabolic health, with mitochondrial function and AMPK activity playing key roles.
Developmental Cell · Jun 15, 2023Peer-reviewedGenetics