Gwendoline Astre

This study models DDR syndromes in killifish and shows that cGAS-STING pathway activation contributes to disease phenotypes, with cGAS mutation partially rescuing defects.

The paper identifies prion-like and phase-separated protein aggregates in aging vertebrate brains using quantitative proteomics in killifish and validates their propagation and functional properties.

This study shows that mutating APRT in turquoise killifish extends male lifespan and improves metabolic health, with mitochondrial function and AMPK activity playing key roles.