Tomer Levy

The paper uses a mechanistic model of aging to show that maximal human lifespan is primarily determined by damage production and clearance rates, with lifestyle factors only modestly affecting it.

The paper presents a theory predicting which longevity interventions compress relative sickspan by steepening the survival curve, supported by evidence from mice, C. elegans, and Drosophila.

This study shows that mutating APRT in turquoise killifish extends male lifespan and improves metabolic health, with mitochondrial function and AMPK activity playing key roles.