Bcl-xL interaction with VDAC1 reduces mitochondrial Ca2+ uptake, allowing the establishment of Therapy-Induced Senescence.
Andrea Puebla-Huerta, Pablo Morgado-Cáceres, Camila Quezada- Gutierez, César Casanova-Canelo, Roberto Rosales-Rojas, José Alberto López-Domínguez, Inés Marin, Sandra Aurora Niño, Pablo Cruz, Micheel Saldivia-Piña, Sergio Linsambarth, Osman Díaz- Rivera, Oscar Cerda, Ariela Vergara-Jaque, Manuel Serrano, , J. César Cárdenas
This study identifies Bcl-xL-VDAC1 interaction as a mechanism that reduces mitochondrial Ca2+ uptake, promoting therapy-induced senescence by preventing apoptosis.
bioRxiv · Dec 8, 2025 · PreprintCell Biology