Manuel Serrano

The paper introduces a targeted metabolomic method to detect epigenetically relevant metabolites using biphasic extraction and stable isotope tracing.

This study shows genetic and chemical partial reprogramming targets senescent cells to reduce aging-related inflammation and improve mitochondrial function in aged mice without restoring proliferation.

This study identifies Bcl-xL-VDAC1 interaction as a mechanism that reduces mitochondrial Ca2+ uptake, promoting therapy-induced senescence by preventing apoptosis.

This study identifies H4K20me3 heterochromatin in persister cancer cells, which reduces their inflammatory profile and reveals vulnerabilities in one-carbon metabolism.

This study shows that transient Yamanaka factor expression during development expands the neocortex and improves cognitive function in mice, while intermittent expression in adult neurons protects against Alzheimer's disease features.

This study uses single-cell RNA sequencing to map the in vivo reprogramming trajectory from acinar cells to pluripotency in the pancreas and identifies conserved intermediate markers across tissues.

The paper introduces ImAge, an image-based biomarker of aging and rejuvenation using chromatin and epigenetic patterns, showing correlation with chronological age and response to interventions.

This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.