Cell BiologybioRxivPreprint
Bcl-xL interaction with VDAC1 reduces mitochondrial Ca2+ uptake, allowing the establishment of Therapy-Induced Senescence.
Andrea Puebla-Huerta, Pablo Morgado-Cáceres, Camila Quezada- Gutierez…·J. César Cárdenas
This study identifies Bcl-xL-VDAC1 interaction as a mechanism that reduces mitochondrial Ca2+ uptake, promoting therapy-induced senescence by preventing apoptosis.
DOI 10.64898/2025.12.05.692660