EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUS
Radharani Benvenutti, Danielle do Carmo Ferreira Bruno, Matheus Gallas‐Lopes, Morten Trillingsgaard Venø, Estela M. Bruxel, Tammy Strickland, Arielle Ramsook, Aditi Wadgaonkar, Yiyue Jiang, Amaya Sanz‐Rodriguez, Lasse Sinkkonen, Marina K. M. Alvim, Clarissa Lin Yasuda, Fábio Rogério, Fernando Cendes, , Cristina Ruedell Reschke
This study shows that epileptogenesis disrupts the circadian clock and alters diurnal transcriptomic rhythms in the mouse hippocampus, with implications for human epilepsy.
bioRxiv · Jul 2, 2024 · PreprintNeuroscience