Perturb-ME: Scalable mechanism discovery from phenotype-enriched genome-wide screens
Hanchen Wang, Jiacheng Gu, Chris J. Frangieh, Michael S. Cuoco, Maryann Zhao, Arindam Sett, Tom Beyer, Kuan Pang, Etzard Stolte, Zihan Xu, Jure Leskovec, Orit Rozenblatt–Rosen, Vivek Natarajan, Kathryn Geiger-Schuller, Pratiksha I. Thakore, Aviv Regev
Perturb-ME combines CRISPR screening and single-cell profiling to identify regulatory modules governing gene programs in melanoma.
bioRxiv · Aug 20, 2026 · PreprintCell Biology