Jiacheng Gu

Perturb-ME combines CRISPR screening and single-cell profiling to identify regulatory modules governing gene programs in melanoma.

CRISPRmap enables multi-omic optical pooled screens to map gene function in cells and tissue without sequencing, identifying pathogenic mutations and analyzing spatial phenotypes.

This study identifies cell type innovations in salamander forebrain evolution, showing similarities to both sauropsid DVR and mammalian neocortex.