Aβ toxicity rescued by protein retention in the ER
James H. Catterson, Lucy J. Minkley, Salomé Aspe, Sebastian Judd-Mole, Sofia Moura, Miranda C. Dyson, Arjunan Rajasingam, Nathaniel S. Woodling, Magda Luciana Atilano, Mumtaz Ahmad, Claire S. Durrant, Tara L. Spires‐Jones, Linda Partridge
This study shows that retaining proteins in the ER can rescue Aβ toxicity in Drosophila and mouse models, suggesting a potential therapeutic strategy for Alzheimer's disease.
Neurobiology of Aging · Sep 21, 2023Peer-reviewedNeuroscience