GTP biosynthesis is a therapeutic vulnerability in Rac1-mutant melanoma
Samson Eugin Simon, Tiannan Wang, Arsha Sreekumar, Zaria Yearby, Isha Patel, Varsha Tandra, Catherine C. Hedrick, Jie Li, David W. Wolff
This study shows that inhibiting GTP biosynthesis, specifically IMPDH, can suppress Rac1P29S mutant melanoma and enhance responses to MAPK inhibitors.
bioRxiv · Sep 24, 2026 · PreprintCancer Biology