Jie Li

This study shows that inhibiting GTP biosynthesis, specifically IMPDH, can suppress Rac1P29S mutant melanoma and enhance responses to MAPK inhibitors.

This study shows that NAE1-dependent neddylation maintains endothelial identity and vascular integrity by preventing pyroptosis and inflammation.

This study shows that neddylation regulates mitochondrial dynamics and turnover in the adult heart, linking its disruption to cardiomyopathy and heart failure.

This study identifies RBX2 as a key component of the CRL5 ubiquitin ligase that regulates mitophagy in cardiomyocytes independently of PARKIN, maintaining cardiac homeostasis.