Samson Eugin Simon

This study shows that inhibiting GTP biosynthesis, specifically IMPDH, can suppress Rac1P29S mutant melanoma and enhance responses to MAPK inhibitors.

This study shows that PDE10A inhibition with ADT-030 suppresses tumor growth by disrupting MAPK signaling and enhancing antitumor immunity through immune cell modulation.

This study shows indomethacin enhances chemo-immunotherapy in mice through both COX-dependent and independent mechanisms, including RAS inhibition.

The paper develops a novel murine model to identify genetic modifiers of triple-negative breast cancer traits and identifies susceptibility loci with potential translational relevance.