Author

David W. Wolff

Augusta UniversityORCID 0000-0003-4201-3857Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Catherine C. HedrickiD· 2 shared Samson Eugin SimoniD· 2 shared Arsha Sreekumar· 1 shared Caitlin Brandle· 1 shared Dongwen LviD· 1 shared Gang ZhouiD· 1 shared Gary Anthony PiazzaiD· 1 shared Huidong ShiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Catherine C. HedrickORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 24, 2026

GTP biosynthesis is a therapeutic vulnerability in Rac1-mutant melanoma

Samson Eugin Simon, Tiannan Wang, Arsha Sreekumar…·David W. Wolff

This study shows that inhibiting GTP biosynthesis, specifically IMPDH, can suppress Rac1P29S mutant melanoma and enhance responses to MAPK inhibitors.

DOI 10.64898/2026.09.23.753957

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintJan 8, 2026

Indomethacin exerts both cyclooxygenase inhibition-dependent and independent mechanisms to enhance chemo-immunotherapy in mice

Ogacheko D. Okoko, Nada S. Aboelella, Yan Ye…·Gang Zhou

This study shows indomethacin enhances chemo-immunotherapy in mice through both COX-dependent and independent mechanisms, including RAS inhibition.

1 citation

mousescRNA-seq

𝕏 PostBluesky