Gain-of-function CRISPR screens identify tumor-promoting genes conferring melanoma cell plasticity and therapy-resistance
Arthur Gautron, Laura Bachelot, Anaïs M. Quéméner, Sébastien Corre, Marc Aubry, Florian Rambow, Anaïs Paris, Nina Tardif, Héloïse M. Leclair, Cédric Coulouarn, Jean-Christophe Marine, Marie-Dominique Galibert, David Gilot
This study identifies tumor-promoting genes via CRISPR screens that confer melanoma cell plasticity and therapy resistance, showing SMAD3's role in BRAFi-resistance and potential as a therapeutic target.
bioRxiv · Jul 8, 2020 · PreprintCancer Biology