The paper identifies WDR91 as a promoter of ASO activity in melanoma through a CRISPR screen, highlighting its role in endosomal maturation and ASO efficacy.

Molecular Therapy — Nucleic Acids · May 24, 2025Peer-reviewedMolecular Biology

Proximity Interactome analyses unveil novel regulators of IRE1a canonical signaling

Simon Le Goupil, Céline Philippe, Hadrien Laprade, Mathéo Lode, Rachel Boniface, Diana Pelizzari‐Raymundo, Kurt Dejgaard, Gregor Jansen, Celia M. Limia, Claudio A. Hetz, Sayyed Jalil Mahdizadeh, Luc Négroni, Marc Aubry, Jean‐Ehrland Ricci, Leif Axel Eriksson, Éric Chevet

The paper identifies novel IRE1 interactors that regulate its RNase activity and stability, revealing new functions in the unfolded protein response.

bioRxiv · Oct 27, 2024 · PreprintBiochemistry

Cirscan: a shiny application to identify differentially active sponge mechanisms and visualize circRNA-miRNA-mRNA networks.

Rose-Marie Fraboulet, Yanis Si Ahmed, Marc Aubry, Sébastien Corre, Marie‐Dominique Galibert, Yuna Blum

Cirscan identifies differentially active circRNA sponge mechanisms and visualizes circRNA-miRNA-mRNA networks from transcriptomic data.

BMC Bioinformatics · Feb 1, 2024Peer-reviewedBioinformatics

Gain-of-function CRISPR screens identify tumor-promoting genes conferring melanoma cell plasticity and therapy-resistance

Arthur Gautron, Laura Bachelot, Anaïs M. Quéméner, Sébastien Corre, Marc Aubry, Florian Rambow, Anaïs Paris, Nina Tardif, Héloïse M. Leclair, Cédric Coulouarn, Jean-Christophe Marine, Marie-Dominique Galibert, David Gilot

This study identifies tumor-promoting genes via CRISPR screens that confer melanoma cell plasticity and therapy resistance, showing SMAD3's role in BRAFi-resistance and potential as a therapeutic target.

bioRxiv · Jul 8, 2020 · PreprintCancer Biology