eIF2B activator prevents neurological defects caused by a chronic Integrated Stress Response
Yao Liang Wong, Lauren LeBon, Ana Maria Basso, Kathy L. Kohlhaas, Arthur L. Nikkel, Holly M. Robb, Diana L. Donnelly‐Roberts, Janani Prakash, Andrew M. Swensen, Nimrod Daniel Rubinstein, Swathi Krishnan, Fiona Elizabeth McAllister, Nicole Haste, Jonathon J. O’Brien, Margaret A. Roy, , Carmela Sidrauski
The paper shows that a novel eIF2B activator prevents neurological defects in a mouse model of Vanishing White Matter disease by normalizing the transcriptome and proteome.
eLife · Jan 9, 2019Peer-reviewedNeuroscience