Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1
Joseph S. Bowness, Tatyana B. Nesterova, Guifeng Wei, Lisa Rodermund, Mafalda R. Almeida, Heather A. Coker, Emma J. Carter, Artun Kadaster, Neil Brockdorff
The paper shows SPEN and Polycomb work together in parallel for Xist-mediated gene silencing, and SmcHD1 recruitment is needed for silencing X-linked genes during differentiation.
Cell Reports · May 1, 2022Peer-reviewedMolecular Biology