Heather A. Coker

The paper identifies a contact-mediated transfer mechanism for Xist RNA localization and spread across the X chromosome.

This study shows Xist RNA localizes to A1-sub-compartments on the X chromosome, which are positioned peripherally in compacted chromosome territories.

This study shows that m6A modification on Xist RNA promotes its turnover, which regulates XCI dynamics, and that the NEXT complex mediates this turnover independently of YTHDC1.

The paper shows SPEN and Polycomb work together in parallel for Xist-mediated gene silencing, and SmcHD1 recruitment is needed for silencing X-linked genes during differentiation.

The paper shows that m6A modification affects alternative intron/exon inclusion in nascent RNA by disrupting splicing when METTL3 is depleted.

The paper visualizes Xist RNA dynamics in single cells during X chromosome inactivation using time-resolved structured illumination microscopy.

The paper systematically analyzes Xist-mediated allelic silencing in ES cells, identifying key factors and their roles in gene silencing during X chromosome inactivation.