Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen
Kendall S. Stocke, Satya Deo Pandey, Shunying Jin, John D. Perpich, Lan Yakoumatos, Hirofumi Kosaki, Daniel Wade Wilkey, Zackary R. Fitzsimonds, Aruna Vashishta, Ian Snider, Mukesh K. Sriwastva, Hong Li, Jiu‐Zhen Jin, Daniel P. Miller, Michael L. Merchant, , Richard John Lamont
This study shows that tyrosine phosphorylation regulates the coupling between one carbon metabolism and virulence in Porphyromonas gingivalis by controlling gingipain protease localization and activity.
Proceedings of the National Academy of Sciences · Sep 29, 2025Peer-reviewedMicrobiology