Author

John D. Perpich

Sullivan UniversityORCID 0000-0002-7884-9202Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Jan PotempaiD· 2 shared Juhi BagaitkariD· 2 shared Richard John LamontiD· 2 shared Aruna Vashishta· 1 shared Barbara Aleksandra PotempaiD· 1 shared Carlos J. Rodriguez HernandeziD· 1 shared Daniel P. MilleriD· 1 shared Daniel Wade WilkeyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMicrobiology

Jan PotempaORCID

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2 papers

Recent·Most cited

Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen

Kendall S. Stocke, Satya Deo Pandey, Shunying Jin, John D. Perpich, Lan Yakoumatos, Hirofumi Kosaki, Daniel Wade Wilkey, Zackary R. Fitzsimonds, Aruna Vashishta, Ian Snider, Mukesh K. Sriwastva, Hong Li, Jiu‐Zhen Jin, Daniel P. Miller, Michael L. Merchant, , Richard John Lamont

This study shows that tyrosine phosphorylation regulates the coupling between one carbon metabolism and virulence in Porphyromonas gingivalis by controlling gingipain protease localization and activity.

Proceedings of the National Academy of Sciences · Sep 29, 2025Peer-reviewedMicrobiology

Virion stripping: A new role for bacterial proteases

Carlos J. Rodriguez Hernandez, Marina Terekhova, Phylip Chen, John D. Perpich, Barbara Aleksandra Potempa, Katherine Carey, Mark E. Peeples, Mitchell H. Grayson, Jan Potempa, Maxim N. Artyomov, Richard John Lamont, Juhi Bagaitkar

This paper shows that Porphyromonas gingivalis proteases reduce viral load and modulate host interferon responses during RSV infection.

bioRxiv · May 3, 2025 · PreprintMicrobiology