TGF-β Coordinates Alanine Synthesis and Import for Myofibroblast Differentiation in Pulmonary Fibrosis
Fei Li, Niv Vigder, David R. Ziehr, Mari Kamiya, Hung N. Nguyen, Diana E. Ferreyra Faustino, Aseel H. Khalil, Hilaire C. Lam, Matthew L. Steinhauser, Edy Yong Kim, William M. Oldham
This study identifies alanine as a critical metabolite regulated by TGF-β that supports myofibroblast differentiation in pulmonary fibrosis through GPT2 and SLC38A2.
JCI Insight · Apr 23, 2026Peer-reviewedCell Biology