Eph-Ephrin Tetramerization Inhibitors Target Bidirectional Signaling to Combat Pain and Addiction
Hanghang Wang, Amav Khambete, Frances Sprouse, Miah Henkemeyer, Melody Karsi, Karina Cortez, Eric Bellinghausen, Tamdan Khuu, Natalie Block, Asghar Talebian, Mahmoud Salama Ahmed, Mahesh Udamulle Gedara, Michael Ortiz, Uttam Tambar, Patrice Nsangou Mimche, Mark J. Henkemeyer
The paper identifies 8-hydroxyquinoline compounds that disrupt EphB-EphrinB tetramer interactions, reducing bidirectional signaling and alleviating pain and opioid withdrawal.
bioRxiv · Dec 25, 2025 · PreprintMolecular Biology