Patrice Nsangou Mimche

This study shows that IL7/IL7R signaling during fetal development programs liver-resident macrophages, which are critical for postnatal immune responses to liver injury.

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

The paper identifies 8-hydroxyquinoline compounds that disrupt EphB-EphrinB tetramer interactions, reducing bidirectional signaling and alleviating pain and opioid withdrawal.

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.