Author

Amav Khambete

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Hanghang WangiD· 3 shared Mark J. HenkemeyeriD· 3 shared Patrice Nsangou MimcheiD· 2 shared Asghar Talebian· 1 shared Eric Bellinghausen· 1 shared Ernest M. Kameni· 1 shared Estelle Atiogue· 1 shared Frances Sprouse· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Hanghang WangORCID

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Author profile →

3 papers

Recent·Most cited

Proteinaceous Metal-Binding Eph-Ephrin Tetramerization is Modulated by Copper and Chelators

Amav Khambete, Hanghang Wang, Mark J. Henkemeyer

The paper identifies EphrinB2 as a copper-binding protein that modulates Eph-Ephrin tetramerization through interactions with copper and chelators.

bioRxiv · Dec 25, 2025 · PreprintMolecular Biology

Eph-Ephrin Tetramerization Inhibitors Target Bidirectional Signaling to Combat Pain and Addiction

Hanghang Wang, Amav Khambete, Frances Sprouse, Miah Henkemeyer, Melody Karsi, Karina Cortez, Eric Bellinghausen, Tamdan Khuu, Natalie Block, Asghar Talebian, Mahmoud Salama Ahmed, Mahesh Udamulle Gedara, Michael Ortiz, Uttam Tambar, Patrice Nsangou Mimche, Mark J. Henkemeyer

The paper identifies 8-hydroxyquinoline compounds that disrupt EphB-EphrinB tetramer interactions, reducing bidirectional signaling and alleviating pain and opioid withdrawal.

bioRxiv · Dec 25, 2025 · PreprintMolecular Biology

Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors

Masaaki Yoshigi, Séverin Donald Kamdem, Hanghang Wang, Amav Khambete, Francis Sprouse, Ernest M. Kameni, Estelle Atiogue, Sarah Pellizzari, Kimberley Jane Evason, My N. Helms, Michael A. Goodman, Shuang Wang, Jisun So, Hyun Cheol Roh, Sihem Boudina, , Patrice Nsangou Mimche

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.

bioRxiv · Nov 19, 2025 · PreprintPathology