Author

Hanghang Wang

The University of Texas Southwestern Medical CenterORCID 0000-0002-9432-0261Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Mark J. HenkemeyeriD· 4 shared Amav Khambete· 3 shared Francis Sprouse· 2 shared Patrice Nsangou MimcheiD· 2 shared Amandine C. TaniD· 1 shared Angus J.M. CameroniD· 1 shared Asghar Talebian· 1 shared Cerian L. BoltoniD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMolecular Biology

Mark J. HenkemeyerORCID

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4 papers

Recent·Most cited

Proteinaceous Metal-Binding Eph-Ephrin Tetramerization is Modulated by Copper and Chelators

Amav Khambete, Hanghang Wang, Mark J. Henkemeyer

The paper identifies EphrinB2 as a copper-binding protein that modulates Eph-Ephrin tetramerization through interactions with copper and chelators.

bioRxiv · Dec 25, 2025 · PreprintMolecular Biology

Eph-Ephrin Tetramerization Inhibitors Target Bidirectional Signaling to Combat Pain and Addiction

Hanghang Wang, Amav Khambete, Frances Sprouse, Miah Henkemeyer, Melody Karsi, Karina Cortez, Eric Bellinghausen, Tamdan Khuu, Natalie Block, Asghar Talebian, Mahmoud Salama Ahmed, Mahesh Udamulle Gedara, Michael Ortiz, Uttam Tambar, Patrice Nsangou Mimche, Mark J. Henkemeyer

The paper identifies 8-hydroxyquinoline compounds that disrupt EphB-EphrinB tetramer interactions, reducing bidirectional signaling and alleviating pain and opioid withdrawal.

bioRxiv · Dec 25, 2025 · PreprintMolecular Biology

Ephrin inhibition disrupts stromal-cancer crosstalk and reduces metastasis in pancreatic cancer

Cerian L. Bolton, Rhianna O’Sullivan, Guillem Fuertes, Francis Sprouse, Hanghang Wang, Shinelle Menezes, Amandine C. Tan, Sabrina Simoncelli, Angus J.M. Cameron, John F. Marshall, Mark J. Henkemeyer, Edward P. Carter, Richard Philip Grose

This study shows that inhibiting Ephrin signaling disrupts stromal-cancer interactions and reduces metastasis in pancreatic cancer using mouse models.

bioRxiv · Dec 13, 2025 · PreprintCancer Biology

Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors

Masaaki Yoshigi, Séverin Donald Kamdem, Hanghang Wang, Amav Khambete, Francis Sprouse, Ernest M. Kameni, Estelle Atiogue, Sarah Pellizzari, Kimberley Jane Evason, My N. Helms, Michael A. Goodman, Shuang Wang, Jisun So, Hyun Cheol Roh, Sihem Boudina, , Patrice Nsangou Mimche

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.

bioRxiv · Nov 19, 2025 · PreprintPathology