Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension
Luke Grundy, Ashlee Caldwell, Sonia Garcia‐Caraballo, David Grundy, Nick J. Spencer, Xinzhong Dong, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
This study identifies MrgprA3 and MrgprC11 as functional receptors on bladder afferents that induce hypersensitivity to distension when activated, offering a potential therapeutic target for bladder disorders.
Journal of Neuroscience · Mar 16, 2021Peer-reviewedNeuroscience