Andrea M. Harrington

This study identifies bladder mucosal afferents as key sensors of UTI, showing they drive pain and urinary frequency during infection, aiding bacterial clearance.

The paper identifies a hypothalamic-hindbrain circuit in mice that suppresses excretion and pelvic pain during movement, enhancing mate-seeking behavior.

This study identifies distinct brainstem circuits activated by splanchnic and pelvic spinal afferent pathways from the mouse colorectum, showing their differential roles in sensory processing and visceromotor responses.

This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.

This study identifies MrgprA3 and MrgprC11 as functional receptors on bladder afferents that induce hypersensitivity to distension when activated, offering a potential therapeutic target for bladder disorders.